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Objective@#To analyze the characteristics of changes in serum cholesterol level in sepsis patients, and to explore its correlation with prognosis.@*Methods@#A retrospective analysis was conducted. Two hundred and six patients with sepsis admitted in the Third People′s Hospital of Dalian from February 2015 to February 2019 were enrolled (observation group), and 206 patients without sepsis hospitalized in the same period were served as control group. The basic clinical data of the two groups were collected, and the results of total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and biochemical parameters were compared. The patients with sepsis were divided into death group and survival group, and risk factors influencing the prognosis of patients with sepsis were analyzed with Logistic regression analysis.@*Results@#Compared with control group, the levels of serum TC [(2.49 ± 1.14) mmol/L vs. (3.40 ± 1.26) mmol/L, t=6.240] and HDL-C [(1.66 ± 0.89) mmol/L vs. (2.49 ± 0.81) mmol/L, t=5.532] in observation group were significantly lower (P<0.05), and that of LDL-C showed no statistically significant difference [(1.96 ± 0.91) mmol/L vs. (2.10 ± 0.72) mmo/L, t=0.940, P>0.05]. In observation group, the patients in death group (85 cases) were older than those of the survival group (121 cases)[(75.6 ± 8.6) years vs. (62.5 ± 6.0) years, t=4.565], serum creatinine (SCr) was higher than that of survival group [(246.2 ± 34.6) μmol/L vs. (165.4 ± 35.6) μmol/L, t=5.420], and the levels of serum TC [(2.15 ± 0.59) mmol/L vs. (2.89 ± 1.02) mmol/L, t= 5.475], HDL-C [(1.40 ± 0.42) mmol/L vs. (1.94 ± 0.52) mmol/L, t=4.856] and LDL-C [(1.73 ± 0.56) mmol/L vs. (1.97 ± 0.72) mmol/L, t=4.261] were significantly lower than those of survival group (P<0.05). Logistic regression analysis showed that age was the risk factor of death in sepsis patients (OR=1.256, 95% CI 1.006 -1.056, P=0.012), and TC was the protective factor for the prognosis of sepsispatients (OR=-0.758, 95%CI 0.579-0.867, P=0.014).@*Conclusions@#The levels of TC, HDL-C in sepsis patients are significantly lowered, and the levels of TC, HDL-C, LDL-C in death group are significantly lower than those in survival group. TC may be used as a clinical indicator to assess the outcome of sepsis patients.
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Objective To analyze the characteristics of changes in serum cholesterol level in sepsis patients,and to explore its correlation with prognosis.Methods A retrospective analysis was conducted.Two hundred and six patients with sepsis admitted in the Third People's Hospital of Dalian from February 2015 to February 2019 were enrolled (observation group),and 206 patients without sepsis hospitalized in the same period were served as control group.The basic clinical data of the two groups were collected,and the results of total cholesterol (TC),low density lipoprotein cholesterol (LDL-C),high density lipoprotein cholesterol (HDL-C) and biochemical parameters were compared.The patients with sepsis were divided into death group and survival group,and risk factors influencing the prognosis of patients with sepsis were analyzed with Logistic regression analysis.Results Compared with control group,the levels of serum TC [(2.49 ± 1.14) mmoFL vs.(3.40 ± 1.26) mmoFL,t =6.240] and HDL-C [(1.66 ± 0.89) mmol/L vs.(2.49 ± 0.81) mmol/L,t =5.532] in observation group were significantly lower (P ＜ 0.05),and that of LDL-C showed no statistically significant difference [(1.96 ± 0.91) mmol/L vs.(2.10 ± 0.72) mmo/L,t =0.940,P＞0.05].In observation group,the patients in death group (85 cases)were older than those of the survival group (121 cases)[(75.6 ± 8.6) years vs.(62.5 ± 6.0) years,t =4.565],serum creatinine (SCr) was higher than that of survival group [(246.2 ± 34.6) μmol/L vs.(165.4 ± 35.6)μ mol/L,t =5.420],and the levels of serum TC [(2.15 ± 0.59) mmol/L vs.(2.89 ± 1.02) mmol/L,t =5.475],HDL-C [(1.40 ± 0.42) mmol/L vs.(1.94 ± 0.52) mmol/L,t =4.856] and LDL-C [(1.73 ± 0.56)mmol/L vs.(1.97 ± 0.72) mmol/L,t =4.261] were significantly lower than those of survival group (P＜0.05).Logistic regression analysis showed that age was the risk factor of death in sepsis patients (OR =1.256,95％ CI 1.006-1.056,P=0.012),and TC was the protective factor for the prognosis of sepsispatients (OR =-0.758,95％CI 0.579-0.867,P =0.014).Conclusions The levels of TC,HDL-C in sepsis patients are significantly lowered,and the levels of TC,HDL-C,LDL-C in death group are significantly lower than those in survival group.TC may be used as a clinical indicator to assess the outcome of sepsis patients.
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Objective:To understand the status quo of primary medical and health services for home aged dementia patients in Weifang from the perspective of medical service providers. And to provide suggestions for improving the primary medical services and community care for home aged dementia patients.Methods:A semi-structured in-depth interview was conducted with 26 primary medical and health care workers in the primary medical and health services of home patients with senile dementia, and the interview data were summarized and extracted by content analysis method.Results:Four themes were extracted according to the primary medical and health services for home aged dementia patients. Theme 1: less chance to contact with dementia patients, and the understanding of the disease is biased. Theme 2: limited medical services and no targeted services. Theme 3: receive less relevant training and need professional technical support. Theme 4: there is no system of medical support, and an effective model needs to be established.Conclusion:There are few primary medical and health services for home patients with senile dementia, and there are regional differences. It is necessary to increase the understanding of home patients with senile dementia by various means and increase the primary medical services for home patients.
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An exploration was made on the content and methodology of supply chain management of a hospital in line with the fifth edition JCI standard.By means of enhanced management of supply chain procurement,tracking validation,risk management and indicators monitoring,the speed and certainty of relevant processes are improved,with hospital operation effectiveness and efficiency enhanced.